Born in Istanbul in 1981, Sigme Büyükedes undertook study as a soprano in 2001, and took her diploma in voice in 2008 from the Istanbul Conservatory of Music. In 2007 she won the international competition for admission to the Accademia di perfezionamento per cantanti lirici at La Scala in Milan, where she studied under Leyla Gencer, Mirella Freni, Luciana Serra, Renato Bruson, Luigi Alva, James Voughan, Vincenzo Scalera, Michael Hampe, Marco Gandini ed Antonio Albanese. In 2004 she took 4th place in the Siemens International Voice Competition in Istanbul. In 2006 she was a finalist in the Leyla Gencer Voice Competition, also in Istanbul; and in 2007 she took second place in the Chamber Music Voice Competition in her home country, Turkey.
Also in 2007, Büyükedes sang the role of Frau Fluth in Nicolai’s Merry Wives of Windsor at the Istanbul Opera, with musical direction by Erdem Çöloğlu. That same year, she was also chosen for the role of Flordiligi in Mozart’s Così fan tutte under musical director was Ottavio Dantone and stage director was Michael Hampe. In 2008 she sang the roles of the Contessa and Marcellina in The Marriage of Figaro under the musical direction of Giovanni Antonini and stage direction of Giorgio Strehler. In 2009 at La Scala and at the Aalborg Opera in Denmark she sang the Prima Donna in Donizetti’s Le Convenienze ed inconvenienze teatrali, with musical direction by Marco Guidarini and stage direction by Antonio Albanese.
Büyükedes sang Beethoven's Ninth Symphony in 2010 at the opening concert of the Ravello Festival with the chorus of the Teatro di San Carlo in Naples, under the musical direction David Afkham and later made her debut as Leonora in Verdi’s Il Trovatore, conducted by Nicola Paszowski.
In 2011, she sang the role of Anna Verdi's Nabucco, conducted by Riccardo Mutiat the Teatro dell'Opera in Rome.She played the role of Aida at the Philharmonic Theatre during the 2011-2012 season.