Born in Karelia, received her singing training from E. M. Manukhova and Georgi Zastavny at the Rimsky Korsakov Conservatory in her home town of St. Petersburg and also at the Accademia delle Voci in Turin from Franca Mattiucci.
She made her debut at the Teatro Regio in Turin as Lady Macbeth (Macbeth) in 2002 and has since given guest performances in this role in Bologna, Palermo, Ravenna, Trieste, Athens, Dallas, Madrid, Munich and Oviedo, and also on a tour of Japan with La Scala Milan conducted by Riccardo Muti.
She has sung Amelia (Un ballo in maschera) in various Italian opera houses and in Amsterdam; the title role in Hindemith's Sancta Susanna at the Ravenna Festival and in New York (on both occasions under the baton of Riccardo Muti), in Lisbon, at La Scala Milan and in Montpellier; Freia (Das Rheingold) in Lisbon; Tosca in Bologna, in Palermo and at the Bregenz Festival in 2007 and 2008; Donna Elvira (Don Giovanni) in Trieste and Pordenone; Leonora (Il trovatore) in Trieste, Pordenone and at the Bregenz Festival in 2005, and the title role in Norma in Trieste.
She made her role debut as Aida in 2009 at the Bregenz Festival. She has also performed as Lucrezia Contarini in Verdi's I due Foscari in Parma and Modena.
During the 2010–11 season Tatiana Serjan sang Tosca at the Deutsche Oper Berlin and at the Bavarian State Opera and appeared as Lida in Verdi's La battaglia di Legnano at the Teatro dell'Opera in Rome, and Macbeth at the Salzburg' Festival and in Rome (Riccardo Muti conductor).
In 2012 Mrs Serjan sung Macbeth in Munich, Tosca and Ballo in Maschera in Berlin, and Attila at the Teatro dell'Opera in Rome (R. Muti conductor).
Her future engagenent include Due Foscari and Nabucco in Rome,Tosca in Munich Ballo in Maschera in Zurich, Macbeth with the Chicago Symphony Orchestra, Tosca and Nabucco at the Lyryc Opera in Chicago.
On the concert platform Tatiana Serjan has performed in sacred works in her Russian homeland. She has sung excerpts from Norma conducted by Riccardo Muti at the Ravenna Festival and in Bosra (Syria), in Shostakovich's Symphony No. 14 in the Teatro São Carlos in Lisbon and in Verdi's Messa da Requiem with the Philharmonia Orchestra conducted by Riccardo Muti in London and also conducted by Tugan Sokhiev in Toulouse.